R404A Safety Data Sheet (SDS)

1 Identification of the Substance and Supplier

1.1 Product Identifier

1.2 Manufacturer / Supplier Details

1.3 Emergency Telephone Number

National chemical emergency hotline: +86-532-83889090 (24 h); supplier emergency telephone: +86 150 5632 8442.

2 Hazards Identification

2.1 GHS Classification

Note: frostbite from liquid contact with skin or eyes is a physical cryogenic injury; GHS has no separate frostbite hazard class.

2.2 GHS Label Elements

Hazard Statements (H-codes)

• H280 Contains gas under pressure; may explode if heated.
• H336 May cause drowsiness or dizziness.

Precautionary Statements (P-codes)

• P102 Read and understand all safety precautions before handling.
• P261 Avoid breathing gas.
• P271 Use only outdoors or in a well-ventilated area.
• P304+P340 IF INHALED: Remove person to fresh air and keep comfortable for breathing.
• P312 Call a poison center or doctor if you feel unwell.
• P403 Store in a well-ventilated place.

2.3 Other Hazards

• Near-azeotropic Mixture, Temperature glide, system.
• Low temperature Discharge temperatureLow, compressorcarbon deposit RiskLow.
• or frostbite.
• ODP = 0, GWP approx. 3,922, "Kigali Amendment"control GWP HFC Mixture.

3 Composition / Information on Ingredients

3.1 Substance / Mixture

this product RefrigerantMixture,.

3.2 Composition Information

3.3 Impurity Information

4 First-Aid Measures

4.1 Description of First-Aid Measures

General advice:. doctor Description.

Inhalation

• fresh air,.
• If breathing is difficult, administer oxygen.
• ( or, ).
• (CPR).
• Keep the patient warm and at rest, monitor closely and seek medical attention if needed.

Skin contact (frostbite)

• (37～40 ℃)frostbite Body Part,.
• (>40 ℃) or (, ).
• frostbite Body Part,.
• and,,.
• Cover the affected area with a sterile dressing and seek immediate medical attention.

Eye contact

• or 15.
• Body Part.
• Remove contact lenses before rinsing, if present and easy to do.
• doctor.

Ingestion

Not applicable. or, Ingestion.

4.2 Most Important Symptoms and Health Effects

• Inhalation: dizziness, drowsiness, headache,,; and cardiac arrhythmia.
• Skin contact: frostbite(,,, ).
• Eye contact: frostbite,,.
• decomposition products Inhalation: and;refrigerant decomposition products.

4.3 Notes to Physician

• Treat symptomatically, keep the airway clear and give oxygen if needed.
• cardiac arrhythmia.
• class(, ).
• frostbiteperfrostbite, 37～40 ℃, or.
• decomposition products(, ),,.

5 Fire-Fighting Measures

5.1 Suitable Extinguishing Media

Non-flammable. Suitable extinguishing media, carbon dioxide,,,.

5.2 Specific Hazards Arising from the Substance

• steel cylinder,; or,.
• Value.
• and, High temperature or.

5.3 Hazardous Combustion Products

High temperaturedecomposition products: (HF), carbon monoxide(CO), (COF₂).

5.4 Advice for Firefighters

• Self-contained breathing apparatus(SCBA),.
• Move containers from the fire area to open ground if safe to do so.
• Firefighting.
• Isolate the area and keep unauthorized personnel out.
• Spillage Liquefied gas,.

6 Accidental Release Measures

6.1 Personal Precautions and Protective Equipment

• Spillage,,.
• (SCBA),, Low temperatureprotective gloves.
• Approach from upwind.
• Spillage.
• or Spillage.
• Assign an emergency liaison and arrange external support.

6.2 Environmental Precautions

• or enclosed.
• Ventilate the area to disperse the gas.
• Spillageemissions, recovery.
• Avoid release to air, water and soil.

6.3 Methods and Materials for Containment and Clean-Up

ventilation,. oxygen, asphyxiation. Spillagerecoveryrecovery;recovery,.

• steel cylinder Spillage, steel cylinder, or Supplier.
• If recovery is not possible, dilute with water spray while preventing water contamination.

6.4 Reference

8 (Exposure controls / personal protection) 13 (Disposal).

Special warning:Vapourlow-lying areasenclosedoxygen deficiency. enclosed or low-lying areasoxygen(≥ 19.5%),.

7 Handling and Storage

7.1 Precautions for Safe Handling

• enclosed, ventilation or.
• Operators must be trained, follow procedures and hold the required certification.
• Spillage.
• and, oxygen.
• steel cylinder,,,,.
• Accidental release measures equipment.
• No smoking, eating or drinking in the workplace.
• frostbite.
• steel cylinder, tightness.

7.2 Conditions for Safe Storage, including Incompatibilities

• Storage,, ventilation, 40 ℃, ignition source, heat source and.
• steel cylinder, and,,, and.
• and oxygen, and (,, )Flammable,.
• and, Low 0.05 MPa.
• Accidental release measures equipment,.
• Apply two-person receiving and custody control.
• Filling Ratio: ≤ 1.0 kg/L.

7.3 Specific End Use(s)

use,. R125, R143a, R134a "Kigali Amendment"control HFC, Mixturequotaphase-down.

8 Exposure Controls / Personal Protection

8.1 Occupational Exposure Limits

R143a (ACGIH TLV-TWA 1000 ppm).

Prepared in accordance with GBZ 2.1-2019"Occupational exposure limits 1: ", Occupational exposure limits,.

8.2 Monitoring Methods

Gas chromatography(GC-FID or GC-MS);;.

8.3 Engineering Controls

• enclosed, ventilation or.
• Provide safety showers and eyewash stations.
• Spillage.
• Use explosion-proof electrical equipment.

8.4 Personal Protective Equipment

8.5 Hygiene Measures

• Remove contaminated clothing and wash skin after work.
• Maintain good personal hygiene.
• Provide eyewash stations and emergency showers at the workplace.

9 Physical and Chemical Properties

9.1 Basic Physical and Chemical Properties

9.2 Other Safety Data

10 Stability and Reactivity

10.1 Reactivity

Chemically stable at ambient temperature and pressure.

10.2 Chemical Stability

Stable under normal temperature and pressure.

10.3 Possibility of Hazardous Reactions

• High temperature(> 250 ℃), (HF), carbon monoxide(CO), (COF₂).
• and, High temperature or.
• and oxygenoxygen.

10.4 Conditions to Avoid

High temperature, open flames, heat source, steel cylinder,.

10.5 Incompatible Materials

(,,,, ), oxygen.

10.6 Hazardous Decomposition Products

(HF), carbon monoxide(CO), (COF₂), Other /.

10.7 Hazardous Polymerization

No polymerisation occurs.

11 Toxicological Information

11.1 Acute Toxicity

R143a, Inhalation LC50(4 hours)approx. 100,000 ppm.

11.2 Skin Corrosion / Irritation

frostbite,. GHS class: Skin corrosion / class(frostbite).

11.3 Serious Eye Damage / Irritation

frostbite.

11.4 Respiratory or Skin Sensitization

. testingdata.

11.5 Germ Cell Mutagenicity

testing(Ames testing, testing, testing).

11.6 Carcinogenicity

Carcinogenicity. IARC;ACGIH A4 class( class class);EPA D ( class class).

11.7 Reproductive Toxicity

testing Reproductive toxicity, class Reproductive toxicitydata.

11.8 STOT - Single Exposure

• narcotic effects(Category 3): Inhalation at high concentrations central nervous system depression, dizziness, drowsiness, headache,.
• cardiac arrhythmia, or.

11.9 STOT - Repeated Exposure

Low. Inhalationtesting.

11.10 Aspiration Hazard

Inhalation, Inhalation at high concentrations central nervous system depression. decomposition products(, ).

12 Ecological Information

12.1 Ecotoxicity

12.2 Persistence and Degradability

• Main and, Atmospheric Lifetimeapprox. approx. 51 ( R143a component basis).
• Biodegradability: not readily biodegradable.
• Hydrolysis: not readily hydrolysed at ambient temperature.

12.3 Bioaccumulative Potential

log P Low, Low(Low log P = 4.5).

12.4 Mobility in Soil

Water SolubilityLow,..

12.5 PBT and vPvB Assessment

PBT(Persistence, bioaccumulation and toxicity)/ vPvB(Very persistent and very bioaccumulative).

12.6 Other Adverse Environmental Effects

• Ozone depletion potential (ODP)(ODP): 0(Relative CFC-11 = 1).
• Global warming potential (GWP)(GWP, 100 years): 3922(Relative CO₂ = 1).
• Large releases affect the ozone layer and global warming; strictly control emissions and prioritise recovery.

13 Disposal Considerations

13.1 Waste Treatment Methods

13.2 Disposal Precautions

• Regulations, "".
• Protection( 8 ).
• Ensure adequate ventilation to prevent asphyxiation.
• Disposal,.

14 Transport Information

14.1 UN Number

3163(Liquefied gas, (R125/R143a/R134a 44/52/4))

14.2 UN Proper Shipping Name

14.3 Transport Hazard Class

Class 2.2, non-flammable non-toxic gas

14.4 Packing Group

Not applicable( 2 class Packing group).

14.5 Transport Labels

• Main Hazard: Flammable.
• Hazard:.

14.6 Packaging Method

• (steel cylinder), steel cylinder GB 5099"".
• Packaging: 10.9kg disposable cylinder, 400kg T steel cylinder, ISO ISO tank.
• Filling Ratio: ≤ 1.0 kg/L.
• steel cylinder Storage and Transport,.

14.7 Special Precautions by Transport Mode

14.8 Transport Precautions

• and oxygen,,.
• Transport Accidental release measures equipment.
• Transport,.
• Transport,, High temperature.
• Keep away from ignition sources, heat and high-temperature areas during stops.
• Vehicles must be fitted with exhaust flame arresters.
• steel cylinder.

15 Regulatory Information

15.1 Chinese Regulations

• Regulations on the Safety Management of Hazardous Chemicals (State Council Decree No. 591)
• Catalogue of Hazardous Chemicals (2015 edition): listed
• GB 30000 series: GHS classification and labelling
• GB/T 16483-2008: SDS preparation standard
• GBZ 2.1-2019: occupational exposure limits for chemical agents
• ""(TSG 23-2021)
• "Danger Transport": Danger Transport
• Air Pollution Prevention and Control Law of the PRC: greenhouse gas controls
• "": and Danger
• GHS( class) 8
• "Kigali Amendment"HFC quota: controlled
• EU F-Gas Regulations: R404a new equipmentrestricted, R449A, R452A

15.2 International Regulations

• EU REACH Regulations(EC 1907/2006) and CLP Regulations(EC 1272/2008)
• EU F-Gas Regulations(EC 517/2014): control
• EPA SNAP / OSHA HCS 2012 / DOT 49 CFR
• ADR/RID /Danger Transport;IMDG Code;IATA DGR Transport

16 Other Information

16.1 References

• NIOSH Pocket Guide to Chemical Hazards
• International Chemical Safety Card (ICSC)
• NOAA CAMEO Chemicals Database
• PubChem Compound Database
• ASHRAE Handbook — Refrigeration Systems and Applications
• GB/T 16483-2008"Description Value Item"
• GB 30000 " class"
• "Montreal Protocol"Kigali Amendmentapprox.

16.2 Abbreviations and Acronyms

16.3 Disclaimer

Safety Data Sheet (SDS)Prepared in accordance with GB/T 16483-2008 GHS Prepared by,,., Specification or. Regulations, Protection. Description or, Prepared by. data Regulations,.

| Reviewed by: | Approved by: | Hubei Zhongjin Fluorine Chemical Co., Ltd.